Betsy Manos, MS
383 Colorow Way, Rm 153
Recognizing the importance of small molecules and the growing interest in screening them for basic and translational research, this University of Utah Shared Resource provides a low-cost alternative to the purchase of large, costly libraries for individual labs. The Drug Screening Shared Resource serves to aid in the identification of novel compounds for a wide range of interests at the University of Utah.
The Drug Screening Resource at the University of Utah is an established Service/Recharge center that provides compound collections for screening by University of Utah Faculty. Our mission is to provide customers low-cost and efficient access to chemical libraries for screening, to equipment for automation, and to synthetic chemistry support for the characterization and validation of compounds for potential use as therapeutics, diagnostics and biological tools.
Products and Services
A. Commercial Compound Libraries Available for Screening
1. Chembridge 49K Diverset
50,000 drug-like small molecules selected on basis of 3-D pharmacaphore analysis.
2. Microsource Spectrum Collection
2000 compounds with varied of biological activity and structural diversity, including 1000 known drugs from United States, Europe, and Japan.
3. Kinase Inhibitor Library
160 well-characterized, cell-permeable, potent, and reversible protein kinase inhibitors, the majority of which are ATP-competitive.
Click here for more information
B. *Private Chemical Collections
4. Dept of Chemistry Library
A diverse collection of molecular skeletons that represent the chemical interests of individual principal investigators. These compounds are all prepared by chemical synthesis within their laboratories and generally reflect natural product substructures or analogues of proven pharmacophores.
5. Ireland Natural Product Collection
A set of natural products isolated from marine invertebrate animals and micro-organisms. The collection reflects a wide array of natural product scaffolds and biosynthetic pathways. All compounds have been purified by HPLC and chemically characterized.
6. UUPCC – University of Utah Private Chemical Collection
A library of 120,000 compounds obtained from the former NPS Pharmaceutical Company. Over 75,000 of these molecules are unique and not commercially available, creating a valuable resource for the University. Due to the unique nature of this library, access will require a written proposal.
7. The CIT Fragment Library
A unique collection of over 1000 molecular fragments created by the Center for Investigational Therapeutics at the Huntsman Cancer Institute. By screening this collection, one can cover larger chemical space and the high structural diversity helps avoid intellectual property conflicts.
8. Spider venom Collection
A small library, also obtained from NPS. Available soon.
* These sets of molecules are proprietary and users will be asked to sign an intellectual property advisory notice.
HCI Research Informatics Shared Resource has developed a database (CSAM) to store data resulting from compound screening. Investigators can access information on the activity of compounds based on results of other researchers' assays.
The DSR has liquid handling equipment available to users. These include:
• 2 Matrix PlateMates - one for 96-well plates and one for 384-well plates
• Biotek Synergy 4 Plate reader – capable of high-throughput reading of fluorescence, luminescence and absorbance at any wavelengths.
• Biotek Plate Washer with stackers.
E. Coming Soon
• Virtual Chemistry screening
• Synthetic chemistry support
• Follow-up assays on hits
Drug Screening Governance
Betsy Manos, MS
Faculty Advisory Committee Members
David Bearss, PhD
David Jones, PhD
Dean Li, MD, PhD
Darrell Davis, PhD
Matthew Sigman PhD
Ryan Looper, PhD
Health Sciences Core Facility: http://www.cores.utah.edu/index.html