In broad terms my lab is interested in the transcriptional control of cellular proliferation and how these controls are subverted in human malignancy. We are currently focused on understanding how cells communicate information about their metabolic state to the nucleus to ultimately drive adaptive changes in gene expression. Furthermore, we are interested in how these metabolic signals coordinate with the signals that control cell growth, division and death. We use a wide array of approaches—from biochemistry to genomics—and studies in both worm and mouse models to examine these questions. Our efforts are focused in two main areas: Communication between mitochondria and the nucleus and the mechanisms of transcriptional repression.