To be diagnosed with MM, a person must have one major condition and one minor condition, or they must have three minor conditions.

Major Conditions:

• Confirmed plasmacytoma (solid tumor of plasma cells)
• Bone marrow sample in which 30% or more cells are plasma cells
• High levels of monoclonal protein (M-protein) in the blood or urine

Minor Conditions:

• Bone marrow sample in which 10-29% cells are plasma cells
• Smaller levels of M-protein levels in blood or urine
• Holes in bones from myeloma growth
• Abnormally low levels of antibodies in the blood